There is a surprise inclusion for 28-year-old Monterrey defender Jose Maria Basanta, who could gain his first international cap.
The selection of Basanta comes after Newcastle defender Fabricio Coloccini was sidelined for three to seven weeks.
The Argentina squad includes Real Madrid forward Angel Di Maria, who will miss the first match through suspension.
Wigan forward Franco Di Santo is among the players named in the squad, along with Manchester City duo Pablo Zabaleta and Sergio Aguero, but there was no place for their team-mate Carlos Tevez.
Argentina play Venezuela on March 22 in Buenos Aires, before going to Bolivia on March 26.
Sabella's team sit three points clear at the top of CONMEBOL qualifying for next year's World Cup, to be staged in Brazil.
Goalkeepers: Mariano Andujar (Catania), Sergio Romero (Sampdoria)
Defenders: Jose-Maria Basanta (Monterrey), Hugo Campagnaro (Napoli), Federico Fernandez (Getafe), Ezequiel Garay (Benfica), Marcos Rojo (Sporting Lisbon), Pablo Zabaleta (Manchester City
Midfielders: Ever Banega (Valencia), Augusto Fernandez (Celta), Pablo Guinazu (Libertad), Angel Di Maria (Real Madrid), Javier Mascherano (Barcelona), Walter Montillo (Santos) Jose Sosa (Metalist)
Forwards: Sergio Aguero (Manchester City), Franco Di Santo (Wigan), Gonzalo Higuain (Real Madrid), Ezequiel Lavezzi (PSG), Lionel Messi (Barcelona), Rodrigo Palacio (Inter Milan)