Liverpool striker Fabio Borini requires surgery on his fractured foot and has been ruled out for three months.
The former Roma striker had to be substituted at half-time after sustaining the injury during Liverpool's 2-1 loss to Manchester United in September.
Borini further aggravated the blow while on international duty with Italy and Liverpool have confirmed the 21-year-old will go under the knife after being assessed at Melwood.
The blow leaves Liverpool with just one senior striker, Luis Suarez, available following their failure to capture Clint Dempsey from Fulham during the transfer window.
A statement from the English Premier League club read: "Liverpool have confirmed Fabio Borini is to undergo an operation on a fractured bone in his foot.
"The forward originally sustained an injury to the area during the recent Anfield clash with Manchester United.
"He then further aggravated the problem resulting in a fracture and returned from international duty with Italy last week.
"Borini was assessed by the club's medical team upon his return to Melwood and a decision was made for the 21-year-old to have surgery.
"Typically, an injury of this nature requires a three-month rehabilitation period."
Youngsters Samed Yesil and Jerome Sinclair have both recently featured in the League Cup and could now be handed further opportunities.
Andy Carroll, who is on loan at West Ham United, cannot be recalled until January.