Olimpia have taken a huge step towards the Copa Libertadores final after a 2-0 win over Santa Fe on Tuesday.
Goals from Herminio Miranda and Juan Carlos Ferreyra saw the three-time champions to the important win in the first leg of the semi-final at Estadio Defensores del Chaco in Asuncion.
Both teams finished the clash with 10 men after Juan Manuel Salgueiro and Gerardo Bedoya were sent off late in the first half.
The Paraguayans are well-placed to reach the final ahead of the second leg on July 9, with the winners to play either Atletico Mineiro or Newell's Old Boys.
The clash came to life in first-half additional time as Salgueiro and Bedoya were given their marching orders.
After the interval, Olimpia took control of the tie, opening the scoring from the penalty spot in the 66th minute.
Alejandro Silva, who came on at half-time, was through one-on-one and tried a cheeky chip over goalkeeper Camilo Vargas.
Vargas made a smart save but brought down Silva as he followed through, giving away a penalty, which Miranda stepped up to convert by sending the goalkeeper the wrong way.
It was a well-worked move which led to the second goal in the 81st minute.
Eduardo Aranda smartly held his pass before putting Silva through, and the substitute's cutback was tapped in by an unmarked Ferreyra.
Colombia's Santa Fe were unable to find an away goal, putting Olimpia in prime position to reach the final.