Nacional booked their spot in the Copa Libertadores knockout stages with a 4-0 thrashing of Toluca on Thursday.
The Uruguayan outfit struck twice in each half as Gonzalo Bueno netted a brace to go with an Israel Damonte effort and Ivan Alonso's penalty.
The win lifted Nacional to 10 points, one ahead of Boca Juniors and five clear of Toluca with one match remaining in Group 1.
Bueno opened the scoring in Montevideo on 11 minutes after he collected a dreadful pass out of defence and rounded goalkeeper Alfredo Talavera before finishing.
The second was a scrappy goal, with Damonte tapping in a Hugo Dorrego cross four minutes after the half hour.
Alonso was clinical from the penalty spot on 74 minutes before a fine team move led to Bueno's second late on.
Olimpia will advance from Group 7 after a 50th-minute strike from Richard Ortiz saw them to a 1-0 win at Universidad de Chile.
The Paraguayans top the group on 10 points with Universidad de Chile third, three points behind Newell's Old Boys.
The Argentines recorded a 3-1 win over Deportivo Lara thanks to Ignacio Scocco's brace and are in prime position to advance to the knockout stages.
Meanwhile, The Strongest moved into second in Group 3 after a 2-1 win at home to Sao Paulo.