Millonarios and Cerro Porteno advanced to the quarter-finals of the Copa Sudamericana on Tuesday.
Millonarios accounted for Brazilian club Palmeiras 4-3 on aggregate following a thrilling 3-0 victory at home in the second leg.
The Columbian side, who were beaten 3-0 in the first leg three weeks ago, opened the scoring through Juan Esteban Ortiz in the 35th minute.
Wason Renteria scored a penalty on 61 minutes before Lewis Ochoa handed Millonarios the lead in the tie in the 77th minute.
Palmeiras hopes of a revival were dealt a telling blow when Betinho was sent off with five minutes remaining.
In Asuncion, Cerro Porteno recorded a 4-2 aggregate win over Colon.
Cerro Porteno, who beat the Argentinean outfit 2-1 away in the first leg, repeated the score at General Pablo Rojas Stadium.
Emmanuel Gigliotti opened the scoring for Colon after two minutes, but the advantage lasted just nine minutes as Roberto Nanni levelled proceedings.
Julio Dos Santos put the Paraguayan side in front on 69 minutes, while Colon were left to rue the dismissals of Diego Pozo and Maximiliano Caire in the 77th minute.
The match was marred by riots, as Colon supporters clashed with police and opposition fans.