Javier Aguirre was denied his first win as Espanyol manager after Alvaro Negredo's 90th-minute equaliser for Sevilla.
Aguirre was moments from a perfect start to his Espanyol tenure when the Spain international found space at the back post to prod home Jesus Navas' teasing cross to pinch a 2-2 draw.
The home side started the day bottom of La Liga but went ahead early when Verdu was brought down in the box and cooly slotted the penalty on13 minutes.
Sevilla replied with a penalty after Coke was brought down in the box by Christian Stuani. Ivan Rakitic made no mistake with the conversion but the visitors were stung by Jose Antonio Reyes' sending off shortly before half-time for a second yellow.
Espanyol substitute Simao took advantage four minutes after the restart with a close-range header to make it 2-1 to the home side.
Espanyol move off the bottom with the draw but are two points away from safety while Sevilla stay in 10th.