A solitary Carlos Quintero goal guided Santos to a 1-0 victory over second-placed America at the Estadio Nuevo Corona.
It was Quintero's second goal in as many matches, and both against top-two opposition, as he helped his side into sixth on the league Santos Laguna and Morelia both moved into the Liga MX top eight with home victories on Friday.
table with 12 points - five behind leaders Tigres UANL.
Morelia were forced to see off fightbacks from Pachuca before posting a home 3-2 win.
Jefferson Montero fired Morelia ahead, before Abraham Carreno equalised on the half-hour mark for Pachuca.
Hector Mancilla then struck a brace either side of the interval for Morelia, but Pachuca ensured of a tense finish when Angel Reyna was on target in the 80th minute - but it proved to be only consolation.
Morelia moved into eighth with their second win in three matches, while Pachuca stayed fifth after their three-match winning streak came to an end.