Toluca finished the regular season top of the Liga MX ensuring their automatic advancement to the group stage of the Copa Libertadores.
Enrique Meza's side defeated San Luis 2-0 and will play Guadalajara in the first round of the playoffs next weekend.
Guadalajara were defeated 2-0 by second-placed Tijuana and just scraped into the finals in eighth place.
Leon finished third thanks to a 3-1 win over Atlas and will play sixth-placed Cruz Azul after they drew with Monterrey 1-1.
In other results on Saturday, Morelia beat Santos Laguna 2-0 to take fifth spot, Tigres UANL were locked 1-1 with America, Pachuca edged Jaguares 2-1.
On Sunday, Pumas UNAM beat Atlante 3-2 and Puebla went down to Queretaro 1-0 at home.