Ligue 1 Preview: Top versus bottom, Lyon aim for Europe
Ligue 1 champions Paris Saint-Germain host Stade Brest in the penultimate game of the season on Saturday.
Carlo Ancelotti's side secured the title with a 1-0 victory over Lyon on Sunday courtesy of a second-half strike from Jeremy Menez.
They face a Brest side rooted to the bottom of the table, unable to avoid relegation this season after losing their last nine matches.
Lyon will look to confirm third place and a spot in next season's UEFA Champions League when they travel to the Stade Municipal du Ray to play Nice.
After suffering a heavy 4-0 defeat to relegation-threatened Evian on Sunday, Nice will be desperate to make amends in front of their home fans.
Lille are hoping that any slip-up by Lyon will allow them to move into third place when they face 2012 Ligue 1 champions Montpellier at the Stade de la Mosson.
A 3-0 success over Stade Reims on Friday kept their hopes very much alive, with just two fixtures of their season remaining.
In the battle to avoid relegation Nancy host Bastia at the Stade Marcel Picot, a 3-2 loss to Bordeaux in their last fixture means they occupy 18th spot.
Troyes maintained their survival hopes with a 1-0 success at fellow strugglers Ajaccio on Saturday and will hope to build on that success when they host Bordeaux.
Evian will be safe if Nancy and Troyes fail to win and they beat 11th-placed Valenciennes at the Parc des Sports.
But Valenciennes are in good form and are enjoying a five-match unbeaten run in Ligue 1.
Elsewhere Saint-Etienne meet Marseille at the Stade Geoffroy-Guichard, while Toulouse travel tothe Stade Auguste-Bonal to play Sochaux.
Finally, Stade Reims welcome Lorient to the Stade Auguste-Delaune II, and Rennes play Ajaccio at the Stade de la Route de Lorient.