Pécsi Mecsek Football Club was originally established in 1950 under the name Pécsi Dózsa. They have spent much of their history in the top flight of Hungarian football, although they have occasionally suffered relegations. The team have historic rivalries with a number of other Hungarian sides, including Komlói Bányász and Kaposvári Rákóczi.
After a few years of competing in the lower divisions, the club gained promotion to the top tier for the first time in 1955. Aside from a brief one year spell during the late 1950s, the side spent the next twenty years in the country's top division. In 1970, they competed in their first continental tournament, the Inter-Cities Fairs Cup. In 1973, Pécsi Dózsa merged with four other teams from the city: Pécsi Helyiipari, Pécsi Ércbányász, Pécsi Építők and Pécsi Bányász. As a result, some sources list the club's foundation date as being 1973, rather than 1950.
The 1985-86 season saw Pécsi MFC finish as league runners up. To date, this remains their best ever performance in the top flight. In 1978 and 1987, the team were beaten finalists in the Magyar Kupa. They would reach a third final in 1990 and, on this occasion, would go on to win the match and claim their first major domestic honour. As a result of their cup win, the club also earned the right to represent Hungary in the following season's European Cup Winners' Cup.
The list of the team's most notable former players includes names like Pál Dárdai, Zoltán Gera, Imre Rapp and Antal Róth. Polish international Robert Warzycha and Austrian international Richard Niederbacher are amongst the club's most significant foreign imports.
Pécsi MFC play their home matches at Stadion PMFC, which first opened its doors to the public in 1955. It is currently able to hold a maximum of 7,160 supporters.