Borussia Dortmund star Marco Reus and twins Sven and Lars Bender have withdrawn from Germany's squad due to injuries.
The trio have pulled out of the squad that will face the Republic of Ireland and Sweden in 2014 FIFA World Cup qualifiers on October 11 and 15.
Reus injured his left ankle in Dortmund's surprising 2-0 Bundesliga defeat at Borussia Monchengladbach on Saturday and is expected to miss a fortnight of action.
Reus' club-mate, Sven Bender, suffered a groin injury in the same fixture and had to be substituted.
Leverkusen's Lars Bender has a thigh problem, sustained in Saturday's 1-1 draw against Bayern Munich, and will also miss out.
As a result, Hamburg defender Heiko Westermann has been selected as an injury replacement by manager Joachim Low.
Westermann, 30, has made 26 appearances for Germany, his last coming in a 4-3 friendly defeat to the United States in June.
Germany will confirm their place at next year's World Cup with victory against the Republic of Ireland in Cologne on October 11.