Serie A Preview: Mihajlovic faces Lazio, Roma host Cagliari
Sinisa Mihajlovic's first game in charge of struggling Sampdoria will see them host Lazio - another of his former clubs.
The 44-year-old - who played for Sampdoria from 1994 to 1998 before joining Lazio, where he stayed for six years - was appointed at the Stadio Luigi Ferraris on Wednesday after leaving his role with the Serbia national team.
Sampdoria will hope he can revitalise their fortunes in Serie A after three consecutive defeats before the international break - a run that has left them 18th in the table.
Lazio also come into the game without a win in their last three Serie A matches - a sequence that is part of a wider run of just one victory in their last seven - and will hope to record a first away success of the campaign.
With leaders Roma not playing until Monday, Juventus can move top of the table with an away win at Livorno on Sunday.
Antonio Conte's champions are only a point behind Rudi Garcia's side and will overtake the pacesetters if they collect their fifth straight league victory.
Roma have drawn their last two games after winning their opening 10 and their unbeaten start to the season will be put to the test when they entertain Cagliari.
Ivo Pulga's side have won on their last two visits to the Stadio Olimpico, but have lost three of their previous four Serie A games.
Rafael Benitez's Napoli will look to keep the pressure on Juventus and Roma when they host Parma on Saturday, while Inter travel south to face Bologna as they look to extend their five-match unbeaten run.
Their city rivals Milan have had a torrid start to the season with just three wins from 12 games, and the pressure is beginning to build on coach Massimiliano Allegri after six matches without a victory in all competitions. They welcome Genoa, who have won their last three in a row - to San Siro.
Elsewhere, the Verona derby kicks off the weekend's action on Saturday as Hellas host bottom-placed Chievo in the first meeting of the clubs since 2002, while Vincenzo Montella's Fiorentina travel to the out-of-sorts Udinese, who have lost four of their last five matches.
The final two games see strugglers Sassuolo welcome Atalanta, and second-bottom Catania chase back-to-back wins when they travel to Torino.