Simeone: Falcao is irreplaceable
The star striker will miss Sunday's La Liga clash against Espanyol with a thigh problem, leaving Simeone with a void to fill up front.
But Simeone remains positive the collective group at his disposal can produce a good display without their star man.
"The objective is not to cover for Radamel's absence," Simeone told reporters at a press conference.
"However, we will be going there with the same mentality as we have had recently, with different players and different characteristics to Falcao, while continuing to remain competitive.
"The team is good, there is much competition internally, the players are eager to play and the intent is to enter the field with the people who can get us the best result, especially for the match that we are next preparing for."
Atletico will be facing an out-of-form Espanyol side who joint bottom of the La Liga table with just one point in five matches.
But Simeone is refusing to underestimate Sunday's opponents.
"They always follow a basis similar to us, with balance, stability, and approaching every game based on the characteristics of their players and on those of their opponents," he said.
"It is why we are changing for this game and will continue to change based on who we have available. They are a team with fewer points than they deserve, that's for sure."