1. FC Slovácko, usually known more simply as Slovácko, was first established in 1927 under the name SK Staré Město. Prior to the turn of the new millennium, Staré Město became known as FC Synot. In 2000, the club joined forces with a team called Slovácká Slavia Uherské Hradiště to become 1. FC Synot. The side went on to adopt its current name prior to the start of the 2004-05 season.
For many decades, the team played in the lower leagues of Czechoslovakia, never reaching the country's top tier. After the Czech Republic became an independent state, the club began its rise to prominence. In 1996-97, they were winners of the Moravian–Silesian Football League and gained promotion to the second tier of Czech football. In 1999-00, they won the Druhá Liga and advanced to the country's top flight, the Gambrinus Liga. This marked their first ever appearance in either Czechoslovakia or the Czech Republic's highest division.
The club's initial stay in the Gambrinus Liga lasted for seven years, before they were relegated in 2007. They returned once again in 2009, despite finishing 10th, after purchasing the top flight license of FC Zenit Čáslav, who had finished in 2nd place. The Czech Cup has provided Slovácko with their closest brushes with major success. In both the 2004-05 and 2008-09 seasons, they reached the final of the competition, before losing to Baník Ostrava and FK Teplice, respectively. Slovácko have also represented their country in continental competition on multiple occasions.
Amongst the most notable players to play for the team are Czech Republic internationals like Daniel Kolář and Jan Rajnoch.
Slovácko play their home matches at the Městský Fotbalový Stadion Miroslava Valenty, which opened its doors in 2003. The stadium is able to hold a maximum of 8,121 spectators and has been used by the Czech national team.