Anderlecht moved six points clear atop the Belgian First Division with a 1-0 win over Mechelen on Saturday.
The reigning champions took advantage of second-placed Zulte-Waregem's home loss to Club Brugge with a slender win in Brussels.
Forward Tom De Sutter broke a seven-match drought in front of goal with the winner for Anderlecht on 58 minutes.
The win ended a run of two matches without a victory for John van den Brom's side.
Goals to Carlos Bacca and Eidur Gudjohnsen in the second half helped Club Brugge to a terrific 2-1 away win at Zulte-Waregem.
Former Chelsea and Barcelona striker Gudjohnsen has now scored two goals in his past two matches for the club he joined in January.
Third-placed Genk came from behind to record a 3-2 home win over Gent.
Thomas Buffel fired Genk in front after seven minutes but strikes from Rodgers Kola and Ilombe Mboyo gave the visitors the lead.
Ghanaian Bennard Kumordzi levelled for the hosts before Julien Gorius bagged a late winner.
Other results saw Standard Liege score twice in both halves in a 4-0 thrashing of OH Leuven while Waasland-Beveren beat Beerschot 3-2.
Mons notched a 3-1 triumph at Cercle Brugge, Lokeren and Sporting Charleroi drew 1-1 and Lierse edged Kortrijk 1-0.