Mathieu Debuchy limped out of yesterdays defeat to Chelsea and will miss Wednesday nights home match against Tottenham Hotspur.
Debuchy joins a long list of first team regulars who are out of action for Newcastle.
Fabricio Coloccini still hasn't recovered from a knee injury, Loic Remy is suspended for one more game after his red card against Norwich and Pappis Cisse is struggling with his fitness.
Alan Pardews selection problems were highlighted yesterday when two of his substitutes, Sylvain Marveaux and Dan Gosling, have hardly featured all season for the Toon Army.
The Toon boss told the Sunday Sun: "Most of the recent results have been impacted by the injuries we've sustained.
"We took another one today in Mathieu who is a big player for us. He got a kick in the calf. I think it will stop him playing on Wednesday.
"Pappis is out, Loic is out, we are missing Cheick and Colo is not with us. We ned those players back, especially for games of the level of Chelsea.
"I know I've said that Sammy Ameobi and Paul Dummett have played well here, but you have got to understand the level that they are at.
"When Chelsea play with the intensity they did today, it's a tough ask to play in these type of games. You need your best players."
Pardew will do well to have a fully fit, experienced squad ready for the mid-week clash with Tottenham.
"Tottenham is a game I would like to think we could get through and hopefully get a strong result.
"After that a lot of our big players will come back to us and I think we will be strong over the next 13 games.
"Then in the summer we have got work to do."