FA Cup Preview: Arsenal face rivals Tottenham, Manchester United host Swansea
Arsenal begin their quest for an 11th FA Cup at home to rivals Tottenham in the third round, while Manchester United entertain Swansea City.
Arsene Wenger's side sit at the top of the Premier League table, but have not won a major trophy since they lifted the FA Cup in 2005.
The Emirates Stadium outfit meet north London neighbours Tottenham in the competition for the first time since April 2001 - when Arsenal won 2-1 in the last four - on Saturday, with perhaps their most famous showdown coming in the 1993 semi-final at Wembley.
Arsenal came out on top on that occasion and went on to complete and FA and League Cup double.
Manchester United - the most successful club in the competition's history with 11 trophy wins - face a tricky home tie against Swansea on Sunday as they look to take the first step towards a first FA Cup win since 2004.
There are three other all-Premier League encounters, as West Brom host Crystal Palace, Cardiff City visit Newcastle United and Norwich City square off with Fulham.
Holders Wigan Athletic, meanwhile, begin their defence against League One outfit MK Dons.
The Championship side won their first major honour with a surprise 1-0 triumph over Manchester City in May under the stewardship of former boss Roberto Martinez.
City begin their attempt to erase those memories at Blackburn Rovers on Saturday.
Elsewhere, seven-times winners Liverpool will hope to avoid a repeat of last year's shock exit to Oldham Athletic when the two meet at Anfield.
A double from striker Matt Smith, now at Leeds United, helped League One side Oldham to a 3-2 victory in the fourth round.
Aston Villa and Sunderland face potential banana skins against Sheffield United and Carlisle United respectively, while Steve McLaren's in-form Derby County face a mouth-watering tie at home to Jose Mourinho's Chelsea, who have lifted the trophy four times in the last seven seasons.
Leicester City and Burnley are two of this season's Championship success stories and the duo have away fixtures at top-flight sides Stoke City and Southampton.
Queens Park Rangers will also look to spring an upset in a trip to Goodison Park to face Everton, while Premier League sides Hull City and West Ham take to the road to face Middlesbrough and Nottingham Forest respectively.
Other fixtures see Barnsley and Yeovil Town welcome League One's Coventry City and Leyton Orient, while Watford and Millwall travel to Bristol City and Southend United.
Non-league duo Kidderminster Harriers and Grimsby Town hope to continue their runs, with the former hosting Peterborough United and the latter entertaining Huddersfield Town. Sheffield Wednesday also face non-league opposition in the form of Macclesfield Town.
Elsewhere, Rochdale meet Leeds United, Charlton Athletic welcome Oxford United to The Valley, Preston North End travel to Ipswich Town, Bournemouth play Burton Albion, Port Vale face Plymouth Argyle and Doncaster Rovers meet Stevenage.
Rounding off the third-round action, there are two all-Championship ties with Bolton Wanderers facing Blackpool and Brighton and Hove Albion's showdown with Reading, while Birmingham City play the winners of Saturday's replay between Bristol Rovers and Crawley Town.