Malaga's ban from playing in European competition has been upheld by the Court of Arbitration for Sport, ratifying UEFA's initial decision.
The club were originally handed the punishment by UEFA's Club Financial Control Body after they failed to meet Financial Fair Play rules due to 'overdue payables' for money owed.
That ruling was taken in December, and was confirmed on Tuesday after Malaga had their appeal rejected, with the CAS rejecting Malaga's claims they had adhered to the FFP regulations.
Malaga had secured qualification for the UEFA Europa League by virtue of a sixth-place finish in La Liga, but their spot in the competition has now been provisionally awarded to ninth-place Sevilla.
Real Vallecano, who finished eighth, would have secured the place but are unable to compete as they have not been granted a UEFA licence.
Malaga participated in last season's UEFA Champions League, and nearly reached the last four before two injury-time goals gave Borussia Dortmund a 3-2 aggregate victory in the quarter-finals.