Panipeirotikos Athlitikos Syllogos Giannina was established in 1966. Usually known as PAS Giannina or simply PAS, the club is based in the Epirus region and has often bounced between the first and second tiers of the Greek league system, spending most of the 1990s outside of the top flight and experiencing major finacial problems in the early 2000s. PAS supporters consider their main rivals to be Olympiakos, AEK Athens, Panathinaikos and OFI Crete.
The team's golden era spanned the 1970s up until the early 1980s. During this time, PAS gained promotion to the top tier of Greek football at the end of the 1973–74 season and subsequently achieved several top half finishes in the division. Their style of play during this era drew special praise from observers, who compared them to Dutch giants Ajax. As a result, the team were sometimes referred to as the 'Ajax of Epirus'.
Though the club has never won a major national honour, they have occasionally challenged near the top of the league table, achieving 5th place finishes in 1975–76 and 1977–78. PAS were crowned as champions of the second tier in 1973–74, 1985–86 and 2001–02 and won the third tier in 1997–98. Their best performances in the Greek Cup came in 2006-07 and 2009-10, where they reached the semi finals.
Notable former PAS Giannina players include Giorgos Donis, Ibrahima Bakayoko and Christos Patsatzoglou, while Alfredo Glasman, Edouard Rigan and Oscar Alvarez are the leading goalscorers in the club's history.
Zosimades Stadium has served as PAS' home since 1966. Originally opened in 1952, the ground has been shared on occasion with other teams, including AE Giannena FC. The stadium currently seats a maximum of 7,534 supporters, but its record attendance was set in 1975, for a match against Olympiakos, which drew 14,557 spectators to the venue.