A second NFC West powerhouse for the second week in a row isn't going to be easy. This is, obviously, going to be a really rough two-week stretch for the Titans. However, this will be a good learning experience as well.
The 49ers defense will bully the Titans offesne, at this point in the season they just aren't ready enough to take on this type of challenge. Chris Johnson will have his worst game of the season and Jake Locker won't have much luck either.
Colin Kaepernick and the San Fran offense will hit in opportune times and the Titans will suffer a loss for the third straight week.
Heading into the bye at 3-4 isn't the worst case scenario for the Titans.
PREDICTION 24-13 (3-4)