Pablo Lima and Liber Quinones both scored twice as Danubio claimed their fifth straight win with a 4-1 triumph over Juventud de las Piedras.
Danubio maintained their one-point lead in Uruguay's Primera Division with the thumping win on Sunday, as their closest rivals River Plate and Nacional both picked up three points as well.
After going behind in the 27th minute to a strike from Juventud's Brazilian striker Marco Antonio, Danubio equalised just after the half-hour mark through Lima.
Quinones put Danubio ahead in the 60th minute and six minutes later Lima ensured the home side were in control at the Estadio Jardines del Hipodromo.
In the 86th minute, Quinones completed his brace and ended the contest.
Danubio, who have not won the Uruguayan league title since 2007, lead the league on 16 points from six matches, while River Plate and Nacional are both on 15.
River Plate defeated Miramar Misiones 1-0 on Sunday thanks to Bruno Montelongo's 90th-minute strike, while Nacional overcame fourth-placed El Tanque Sisley by the same margin on Friday.
Fenix moved off the bottom of the table with a shock 3-0 win away to Rentistas, rising above Juventud and Miramar.
Penarol's poor start to the season continued as they needed a 73rd-minute equaliser from Marcelo Zalayeta to draw 1-1 with Wanderers.
In other results, Liverpool cruised to a 3-0 win away to Racing, Cerro overcame Sud America 4-2 and Defensor Sporting drew 2-2 with Cerro Largo.