International football rarely gives a new coach the luxury of a long build-up, but 23 days is especially tight when a first qualifier is the starting point.
That matters because first qualifiers can quickly shape the mood around a campaign. A coherent display can buy a coach time. A disjointed one can create noise immediately.
Whatever Guinea lacked in their recent qualifying run, they still appear to have one major problem for opponents: Serhou Guirassy.
For Mosimane, that makes defensive organisation the obvious first priority. Compact spacing between midfield and defence, fewer cheap turnovers, and better control of crosses and second balls should be near the top of the list.
Reports say Mosimane is back in a job he previously held between 2010 and 2012, a spell that ended badly. That history will follow him. So will his stronger club record.
That is the long view. The short view is Guinea. If South Africa look organised and handle Guirassy well, Mosimane will have a platform. If not, the scrutiny will start before the campaign has properly settled.