The biggest blow is not just finishing.
Reports say he has not played since January because of a quadriceps injury, with a recovery setback ending hopes of a return in time for the tournament. That matters because Ghana are not simply replacing a name; they are replacing a player who can change the rhythm of an attack on his own.
Without Kudus, Carlos Queiroz may have to build a more direct front line around Inaki Williams and Antoine Semenyo, who are expected to carry more of the threat.
That could mean:
Williams gives Ghana depth and movement. Semenyo can offer power and vertical running. But Kudus usually supplies the connective tissue between midfield and attack. Without him, Ghana may become more straightforward and easier to read against elite opponents.
That tactical shift looks even more significant in a group featuring Croatia, England and Panama. Against stronger teams, moments of individual quality often decide tight matches. Kudus has been that kind of player for Ghana.
The next key storyline is how Queiroz finalises the balance of his front line before the tournament begins. Ghana still have pace and aggression up top, but without Kudus, the margin for error looks thinner and the need for a clear attacking plan becomes far greater.