Reports suggest Wirtz could move into a more advanced role, potentially taking Harvey Elliott’s place. Isak may also start up front, while Rio Ngumoha is expected to keep his spot after scoring the winner against Wrexham.
Gravenberch’s return gives Iraola another midfield option alongside Dominik Szoboszlai. That could help Liverpool bring more control and forward drive to the centre of the pitch, but the match is also a chance to assess combinations rather than settle on a fixed starting XI.
Rotation has been a feature of the opening two friendlies: only Giorgi Mamardashvili and Elliott started both. Another reshuffle would fit that pattern and give players returning from international duty valuable minutes.
Gomez’s injury removes a versatile defensive option from the selection picture. His absence may open the door to changes across the back four, with Jeremie Frimpong and Milos Kerkez among the players reported as possible starters. Jeremy Jacquet could also feature after recovering from injury.
The challenge for Iraola is to balance those opportunities with continuity. A new-look defence may need time to settle, especially as Liverpool work through a run of pre-season changes.
The Leeds match will show how quickly Liverpool’s returning players can slot into Iraola’s plans-and whether Isak and Wirtz can make an immediate impact together. Gomez’s recovery will remain a storyline beyond Chicago, while the next friendlies should offer a clearer picture of the preferred lineup.